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XRCC3 (NM_005432) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3), transcript variant 2, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

CMM6

Gene ID

7517

UniProt

O43542, Q53XC8

Accession Number mRNA

NM_005432

Chromosomal Location

14q32.33

Expression System

E. coli

Tag

N-His

Related Pathways

Homologous recombination

Field of Research

Homologous recombination

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl

Function

Druggable Genome

Molecular Weight

37.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

XRCC3

Species

Human

Protein ID

NP_005423

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/7517

Uniprot URL

https://www.uniprot.org/uniprot/O43542

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_005432

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_005423

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