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Proteasome 20S beta 7 (PSMB7) (NM_002799) Human Recombinant Protein

Product Specifications

Background

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012]

Overview

Recombinant protein of human proteasome (prosome, macropain) subunit, beta type, 7 (PSMB7), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

Z

Gene ID

5695

UniProt

Q99436, E9KL30

Accession Number mRNA

NM_002799

Chromosomal Location

9q33.3

Expression System

E. coli

Tag

N-His

Related Pathways

Proteasome

Field of Research

Proteasome

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl

Function

Druggable Genome, Protease

Molecular Weight

30

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

PSMB7

Species

Human

Protein ID

NP_002790

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/5695

Uniprot URL

https://www.uniprot.org/uniprot/Q99436

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_002799

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_002790

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