SOCS6 (NM_004232) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]
Synonyms
CIS-4; CIS4; HSPC060; SOCS-4; SOCS-6; SOCS4; SSI4; STAI4; STATI4
Gene ID
9306
UniProt
O14544, A0A024R379
Accession Number mRNA
NM_004232
Chromosomal Location
18q22.2
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl
Function
Druggable Genome
Molecular Weight
59.5
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SOCS6
Species
Human
Protein ID
NP_004223
Overview
Recombinant protein of human suppressor of cytokine signaling 6 (SOCS6), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9306
Uniprot URL
https://www.uniprot.org/uniprot/O14544
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004232
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004223
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