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SDHB (NM_003000) Human Recombinant Protein

Product Specifications

Background

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), nuclear gene encoding mitochondrial protein, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

CWS2; IP; MC2DN4; PGL4; SDH; SDH1; SDH2; SDHIP

Gene ID

6390

UniProt

P21912

Accession Number mRNA

NM_003000

Chromosomal Location

1p36.13

Expression System

E. coli

Tag

N-His

Related Pathways

Alzheimer's disease, Citrate cycle (TCA cycle), Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

Field of Research

Alzheimer's disease, Citrate cycle (TCA cycle), Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl

Function

Druggable Genome

Molecular Weight

31.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

SDHB

Species

Human

Protein ID

NP_002991

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/6390

Uniprot URL

https://www.uniprot.org/uniprot/P21912

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_003000

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_002991

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