PPT1 (NM_000310) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4) . Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2008]
Overview
Recombinant protein of human palmitoyl-protein thioesterase 1 (PPT1), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Synonyms
CLN1; INCL; PPT
Gene ID
5538
UniProt
P50897
Accession Number mRNA
NM_000310
Chromosomal Location
1p34.2
Expression System
E. coli
Tag
N-His
Related Pathways
Fatty acid elongation in mitochondria, Lysosome, Metabolic pathways
Field of Research
Fatty acid elongation in mitochondria, Lysosome, Metabolic pathways
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl
Function
Druggable Genome
Molecular Weight
34.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PPT1
Species
Human
Protein ID
NP_000301
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5538
Uniprot URL
https://www.uniprot.org/uniprot/P50897
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000310
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000301
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