MESD (NM_015154) Human Recombinant Protein
Product Specifications
Background
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs) . Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity) . May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
BOCA; MESDC2; OI20
Gene ID
23184
UniProt
Q14696
Accession Number mRNA
NM_015154
Chromosomal Location
15q25.1
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl
Molecular Weight
26.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MESD
Species
Human
Protein ID
NP_055969
Overview
Recombinant protein of human mesoderm development candidate 2 (MESDC2), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/23184
Uniprot URL
https://www.uniprot.org/uniprot/Q14696
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_015154
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055969
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