MESD (NM_015154) Human Recombinant Protein

Product Specifications

Background

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs) . Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity) . May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity) .[UniProtKB/Swiss-Prot Function]

Overview

Recombinant protein of human mesoderm development candidate 2 (MESDC2), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

BOCA; MESDC2; OI20

Gene ID

23184

UniProt

Q14696

Accession Number mRNA

NM_015154

Chromosomal Location

15q25.1

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl

Molecular Weight

26.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.