RGS18 (NM_130782) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human regulator of G-protein signaling 18 (RGS18), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Synonyms
RGS13
Gene ID
64407
UniProt
Q9NS28
Accession Number mRNA
NM_130782
Chromosomal Location
1q31.2
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl
Molecular Weight
27.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RGS18
Species
Human
Protein ID
NP_570138
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/64407
Uniprot URL
https://www.uniprot.org/uniprot/Q9NS28
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_130782
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_570138
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