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SHMT2 (NM_005412) Human Recombinant Protein

Product Specifications

Background

This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Synonyms

GLYA; HEL-S-51e; NEDCASB; SHMT

Gene ID

6472

UniProt

P34897, V9HW06, Q5BJF5

Accession Number mRNA

NM_005412

Chromosomal Location

12q13.3

Expression System

E. coli

Tag

N-His

Related Pathways

Cyanoamino acid metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Methane metabolism, One carbon pool by folate

Field of Research

Cyanoamino acid metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Methane metabolism, One carbon pool by folate

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl

Molecular Weight

56

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

SHMT2

Species

Human

Protein ID

NP_005403

Overview

Recombinant protein of human serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), nuclear gene encoding mitochondrial protein, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/6472

Uniprot URL

https://www.uniprot.org/uniprot/P34897

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_005412

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_005403

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