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IHO1 (NM_178173) Human Recombinant Protein

Product Specifications

Background

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.[UniProtKB/Swiss-Prot Function]

Overview

Recombinant protein of human coiled-coil domain containing 36 (CCDC36), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

CCDC36; CT74; LELA1

Gene ID

339834

UniProt

Q8IYA8

Accession Number mRNA

NM_178173

Chromosomal Location

3p21.31

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl

Molecular Weight

65.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

IHO1

Species

Human

Protein ID

NP_835467

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/339834

Uniprot URL

https://www.uniprot.org/uniprot/Q8IYA8

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_178173

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_835467

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