IHO1 (NM_178173) Human Recombinant Protein
Product Specifications
Background
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.[UniProtKB/Swiss-Prot Function]
Synonyms
CCDC36; CT74; LELA1
Gene ID
339834
UniProt
Q8IYA8
Accession Number mRNA
NM_178173
Chromosomal Location
3p21.31
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl
Molecular Weight
65.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
IHO1
Species
Human
Protein ID
NP_835467
Overview
Recombinant protein of human coiled-coil domain containing 36 (CCDC36), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/339834
Uniprot URL
https://www.uniprot.org/uniprot/Q8IYA8
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_178173
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_835467
Curated Selection
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