PRPK (TP53RK) (NM_033550) Human Recombinant Protein
Product Specifications
Background
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t (6) A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914) . The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914) . TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity) . Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806) .[UniProtKB/Swiss-Prot Function]
Synonyms
BUD32; C20orf64; dJ101A2; GAMOS4; Nori-2; Nori-2p; PRPK; TPRKB
Gene ID
112858
UniProt
Q96S44
Accession Number mRNA
NM_033550
Chromosomal Location
20q13.12
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl
Function
Druggable Genome, Protein Kinase
Molecular Weight
28 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TP53RK
Species
Human
Protein ID
NP_291028
Overview
Recombinant protein of human TP53 regulating kinase (TP53RK), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/112858
Uniprot URL
https://www.uniprot.org/uniprot/Q96S44
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_033550
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_291028
Curated Selection
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