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DAOA (NM_172370) Human Recombinant Protein

Product Specifications

Background

This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Mar 2011]

Overview

Recombinant protein of human D-amino acid oxidase activator (DAOA), transcript variant 11, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

LG72; SG72

Gene ID

267012

UniProt

P59103

Accession Number mRNA

NM_172370

Chromosomal Location

13q34

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl

Function

Druggable Genome

Molecular Weight

17.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

DAOA

Species

Human

Protein ID

NP_758958

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/267012

Uniprot URL

https://www.uniprot.org/uniprot/P59103

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_172370

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_758958

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