Telethonin (TCAP) (NM_003673) Human Recombinant Protein
Product Specifications
Background
Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human titin-cap (telethonin) (TCAP), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Synonyms
CMD1N; CMH25; LGMD2G; LGMDR7; T-cap; TELE; telethonin
Gene ID
8557
UniProt
O15273, A2TDC0
Accession Number mRNA
NM_003673
Chromosomal Location
17q12
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Molecular Weight
18.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TCAP
Species
Human
Protein ID
NP_003664
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8557
Uniprot URL
https://www.uniprot.org/uniprot/O15273
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003673
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003664
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