Telethonin (TCAP) (NM_003673) Human Recombinant Protein

Product Specifications

Background

Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human titin-cap (telethonin) (TCAP), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

CMD1N; CMH25; LGMD2G; LGMDR7; T-cap; TELE; telethonin

Gene ID

8557

UniProt

O15273, A2TDC0

Accession Number mRNA

NM_003673

Chromosomal Location

17q12

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.

Molecular Weight

18.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.