Caspase-6 (CASP6) (NM_001226) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]
Overview
Recombinant protein of human caspase 6, apoptosis-related cysteine peptidase (CASP6), transcript variant alpha, with N-terminal HIS tag, expressed in E.Coli, 50ug
Synonyms
MCH2
Gene ID
839
UniProt
P55212
Accession Number mRNA
NM_001226
Chromosomal Location
4q25
Expression System
E. coli
Tag
N-His
Related Pathways
Apoptosis
Field of Research
Apoptosis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Function
Druggable Genome, Protease, Stem cell - Pluripotency
Molecular Weight
33.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CASP6
Species
Human
Protein ID
NP_001217
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/839
Uniprot URL
https://www.uniprot.org/uniprot/P55212
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001226
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001217
Frequently Asked Questions
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