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Caspase-6 (CASP6) (NM_001226) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]

Overview

Recombinant protein of human caspase 6, apoptosis-related cysteine peptidase (CASP6), transcript variant alpha, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

MCH2

Gene ID

839

UniProt

P55212

Accession Number mRNA

NM_001226

Chromosomal Location

4q25

Expression System

E. coli

Tag

N-His

Related Pathways

Apoptosis

Field of Research

Apoptosis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.

Function

Druggable Genome, Protease, Stem cell - Pluripotency

Molecular Weight

33.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

CASP6

Species

Human

Protein ID

NP_001217

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/839

Uniprot URL

https://www.uniprot.org/uniprot/P55212

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001226

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001217

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