RIOK2 (NM_018343) Human Recombinant Protein
Product Specifications
Background
Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402) . Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710) .[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human RIO kinase 2 (RIOK2), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Synonyms
RIO2
Gene ID
55781
UniProt
Q9BVS4
Accession Number mRNA
NM_018343
Chromosomal Location
5q15
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Function
Druggable Genome, Protein Kinase
Molecular Weight
63.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RIOK2
Species
Human
Protein ID
NP_060813
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/55781
Uniprot URL
https://www.uniprot.org/uniprot/Q9BVS4
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_018343
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_060813
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