TGIF (TGIF1) (NM_174886) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
Synonyms
HPE4; TGIF
Gene ID
7050
UniProt
Q15583
Accession Number mRNA
NM_174886
Chromosomal Location
18p11.31
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Function
Druggable Genome, Stem cell - Pluripotency, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transcription Factors
Molecular Weight
27.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TGIF1
Species
Human
Protein ID
NP_777480
Overview
Recombinant protein of human TGFB-induced factor homeobox 1 (TGIF1), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7050
Uniprot URL
https://www.uniprot.org/uniprot/Q15583
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_174886
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_777480
Curated Selection
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