CREB1 (NM_004379) Human Recombinant Protein
Product Specifications
Background
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Synonyms
CREB; CREB-1
Gene ID
1385
UniProt
P16220, Q53X93
Accession Number mRNA
NM_004379
Chromosomal Location
2q33.3
Expression System
E. coli
Tag
N-His
Related Pathways
Antigen processing and presentation, Huntington's disease, Melanogenesis, Prostate cancer
Field of Research
Antigen processing and presentation, Huntington's disease, Melanogenesis, Prostate cancer
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Function
Druggable Genome, Transcription Factors
Molecular Weight
35 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CREB1
Species
Human
Protein ID
NP_004370
Overview
Recombinant protein of human cAMP responsive element binding protein 1 (CREB1), transcript variant A, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1385
Uniprot URL
https://www.uniprot.org/uniprot/P16220
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004379
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004370
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