CREB1 (NM_004379) Human Recombinant Protein

Product Specifications

Background

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Overview

Recombinant protein of human cAMP responsive element binding protein 1 (CREB1), transcript variant A, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

CREB; CREB-1

Gene ID

1385

UniProt

P16220, Q53X93

Accession Number mRNA

NM_004379

Chromosomal Location

2q33.3

Expression System

E. coli

Tag

N-His

Related Pathways

Antigen processing and presentation, Huntington's disease, Melanogenesis, Prostate cancer

Field of Research

Antigen processing and presentation, Huntington's disease, Melanogenesis, Prostate cancer

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.

Function

Druggable Genome, Transcription Factors

Molecular Weight

35 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.