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BID (NM_197966) Human Recombinant Protein

Product Specifications

Background

This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8) ; CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Aug 2020]

Overview

Recombinant protein of human BH3 interacting domain death agonist (BID), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

FP497

Gene ID

637

UniProt

P55957, B3KT21

Accession Number mRNA

NM_197966

Chromosomal Location

22q11.21

Expression System

E. coli

Tag

N-His

Related Pathways

Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Pathways in cancer, Viral myocarditis

Field of Research

Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Pathways in cancer, Viral myocarditis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.

Function

Druggable Genome

Molecular Weight

26.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

BID

Species

Human

Protein ID

NP_932070

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/637

Uniprot URL

https://www.uniprot.org/uniprot/P55957

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_197966

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_932070

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