COP (CARD16) (NM_001017534) Human Recombinant Protein
Product Specifications
Background
Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.[UniProtKB/Swiss-Prot Function]
Synonyms
COP; COP1; PSEUDO-ICE
Gene ID
114769
UniProt
Q5EG05
Accession Number mRNA
NM_001017534
Chromosomal Location
11q22.3
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl
Molecular Weight
22.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CARD16
Species
Human
Protein ID
NP_001017534
Overview
Purified recombinant protein of Human caspase recruitment domain family, member 16 (CARD16), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/114769
Uniprot URL
https://www.uniprot.org/uniprot/Q5EG05
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001017534
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001017534
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