PRAK (MAPKAPK5) (NM_003668) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]
Synonyms
MAPKAP-K5; MK-5; MK5; PRAK
Gene ID
8550
UniProt
Q8IW41
Accession Number mRNA
NM_003668
Chromosomal Location
12q24.12-q24.13
Expression System
E. coli
Tag
N-His
Related Pathways
MAPK signaling pathway
Field of Research
MAPK signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl
Function
Druggable Genome, Protein Kinase
Molecular Weight
53.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MAPKAPK5
Species
Human
Protein ID
NP_003659
Overview
Purified recombinant protein of Human mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8550
Uniprot URL
https://www.uniprot.org/uniprot/Q8IW41
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003668
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003659
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