Dectin 1 (CLEC7A) (NM_197950) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Synonyms
BGR; CANDF4; CD369; CLECSF12; DECTIN1; SCARE2
Gene ID
64581
UniProt
Q9BXN2, Q68D78
Accession Number mRNA
NM_197950
Chromosomal Location
12p13.2
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl
Function
Druggable Genome, Transmembrane
Molecular Weight
19 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CLEC7A
Species
Human
Protein ID
NP_922941
Overview
Purified recombinant protein of Human C-type lectin domain family 7, member A (CLEC7A), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/64581
Uniprot URL
https://www.uniprot.org/uniprot/Q9BXN2
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_197950
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_922941
Curated Selection
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