CREM (NM_182771) Human Recombinant Protein
Product Specifications
Background
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
Overview
Purified recombinant protein of Human cAMP responsive element modulator (CREM), transcript variant 15, with N-terminal HIS tag, expressed in E.Coli, 50ug
Synonyms
CREM-2; hCREM-2; ICER
Gene ID
1390
UniProt
Q03060
Accession Number mRNA
NM_182771
Chromosomal Location
10p11.21
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl
Function
Druggable Genome, Transcription Factors
Molecular Weight
29.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CREM
Species
Human
Protein ID
NP_877572
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1390
Uniprot URL
https://www.uniprot.org/uniprot/Q03060
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_182771
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_877572
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