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RAD51C (NM_002876) Human Recombinant Protein

Selected Variant

PH31958E1

Size: 50 µg

Product Specifications

Background

This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Overview

Purified recombinant protein of Human RAD51 homolog C (S. cerevisiae) (RAD51C), transcript variant 2, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

BROVCA3; FANCO; R51H3; RAD51L2

Gene ID

5889

UniProt

O43502

Accession Number mRNA

NM_002876

Chromosomal Location

17q22

Expression System

E. coli

Tag

N-His

Related Pathways

Homologous recombination

Field of Research

Homologous recombination

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.

Function

Druggable Genome

Molecular Weight

14.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

RAD51C

Species

Human

Protein ID

NP_002867

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/5889

Uniprot URL

https://www.uniprot.org/uniprot/O43502

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_002876

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_002867

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