MGP (NM_000900) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. [provided by RefSeq, Sep 2016]
Synonyms
GIG36; MGLAP; NTI
Gene ID
4256
UniProt
P08493, A0A024RAX0
Accession Number mRNA
NM_000900
Chromosomal Location
12p12.3
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Function
Secreted Protein
Molecular Weight
12.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MGP
Species
Human
Protein ID
NP_000891
Overview
Purified recombinant protein of Human matrix Gla protein (MGP), transcript variant 2, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4256
Uniprot URL
https://www.uniprot.org/uniprot/P08493
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000900
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000891
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