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Calcipressin 1 (RCAN1) (NM_203418) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Overview

Purified recombinant protein of Human regulator of calcineurin 1 (RCAN1), transcript variant 3, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

ADAPT78; CSP1; DSC1; DSCR1; MCIP1; RCN1

Gene ID

1827

UniProt

P53805, Q6FGP2

Accession Number mRNA

NM_203418

Chromosomal Location

21q22.12

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, 8M Urea, pH8.0.

Function

Transcription Factors

Molecular Weight

22.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

RCAN1

Species

Human

Protein ID

NP_981963

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/1827

Uniprot URL

https://www.uniprot.org/uniprot/P53805

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_203418

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_981963

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