NEDD8 (NM_006156) Human Recombinant Protein
Product Specifications
Background
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.[UniProtKB/Swiss-Prot Function]
Synonyms
NEDD-8
Gene ID
4738
UniProt
Q15843
Accession Number mRNA
NM_006156
Chromosomal Location
14q12
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Function
Druggable Genome
Molecular Weight
8.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NEDD8
Species
Human
Protein ID
NP_006147
Overview
Purified recombinant protein of Human neural precursor cell expressed, developmentally down-regulated 8 (NEDD8), with N-terminal HIS tag, expressed in E.Coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4738
Uniprot URL
https://www.uniprot.org/uniprot/Q15843
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_006156
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_006147
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