SINHCAF (NM_001135812) Human Recombinant Protein
Product Specifications
Background
Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288) . Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
C12orf14; FAM60A; L4; TERA
Gene ID
58516
UniProt
Q9NP50
Accession Number mRNA
NM_001135812
Chromosomal Location
12p11.21
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Molecular Weight
24.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SINHCAF
Species
Human
Protein ID
NP_0011292847
Overview
Purified recombinant protein of Human family with sequence similarity 60, member A (FAM60A), transcript variant 3, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/58516
Uniprot URL
https://www.uniprot.org/uniprot/Q9NP50
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001135812
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_0011292847
Curated Selection
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