SINHCAF (NM_001135812) Human Recombinant Protein

Product Specifications

Background

Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288) . Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity) .[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Human family with sequence similarity 60, member A (FAM60A), transcript variant 3, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

C12orf14; FAM60A; L4; TERA

Gene ID

58516

UniProt

Q9NP50

Accession Number mRNA

NM_001135812

Chromosomal Location

12p11.21

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.

Molecular Weight

24.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.