PDE1C (NM_005020) Human Recombinant Protein
Product Specifications
Background
This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]
Overview
Purified recombinant protein of Human phosphodiesterase 1C, calmodulin-dependent 70kDa (PDE1C), transcript variant 4, with N-terminal HIS tag, expressed in E.Coli, 50ug
Synonyms
Cam-PDE 1C; DFNA74; hCam-3; Hcam3
Gene ID
5137
UniProt
Q14123
Accession Number mRNA
NM_005020
Chromosomal Location
7p14.3
Expression System
E. coli
Tag
N-His
Related Pathways
Calcium signaling pathway, Olfactory transduction, Progesterone-mediated oocyte maturation, Purine metabolism
Field of Research
Calcium signaling pathway, Olfactory transduction, Progesterone-mediated oocyte maturation, Purine metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Activity
29860631
Form
Liquid
Buffer
50mM Tris, 8M Urea, pH8.0.
Function
Druggable Genome
Molecular Weight
72 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PDE1C
Species
Human
Protein ID
NP_005011
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5137
Uniprot URL
https://www.uniprot.org/uniprot/Q14123
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005020
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005011
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