PDE1C (NM_005020) Human Recombinant Protein

Product Specifications

Background

This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]

Overview

Purified recombinant protein of Human phosphodiesterase 1C, calmodulin-dependent 70kDa (PDE1C), transcript variant 4, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

Cam-PDE 1C; DFNA74; hCam-3; Hcam3

Gene ID

5137

UniProt

Q14123

Accession Number mRNA

NM_005020

Chromosomal Location

7p14.3

Expression System

E. coli

Tag

N-His

Related Pathways

Calcium signaling pathway, Olfactory transduction, Progesterone-mediated oocyte maturation, Purine metabolism

Field of Research

Calcium signaling pathway, Olfactory transduction, Progesterone-mediated oocyte maturation, Purine metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Activity

29860631

Form

Liquid

Buffer

50mM Tris, 8M Urea, pH8.0.

Function

Druggable Genome

Molecular Weight

72 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.