Integrin Linked Kinase (ILK) (NM_004517) Human Recombinant Protein

Product Specifications

Background

This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Overview

Purified recombinant protein of Human integrin-linked kinase (ILK), transcript variant 1, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

HEL-S-28; ILK-1; ILK-2; P59; p59ILK

Gene ID

3611

UniProt

Q13418, V9HWF0

Accession Number mRNA

NM_004517

Chromosomal Location

11p15.4

Expression System

E. coli

Tag

N-His

Related Pathways

Endometrial cancer, Focal adhesion, PPAR signaling pathway

Field of Research

Endometrial cancer, Focal adhesion, PPAR signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, 8M Urea, pH8.0.

Function

Druggable Genome, Protein Kinase

Molecular Weight

51.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.