HMGB2 (NM_001130689) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V (D) J recombination. [provided by RefSeq, Jul 2008]
Synonyms
HMG2
Gene ID
3148
UniProt
P26583
Accession Number mRNA
NM_001130689
Chromosomal Location
4q34.1
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Function
Druggable Genome, Transcription Factors
Molecular Weight
23.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
HMGB2
Species
Human
Protein ID
NP_001124161
Overview
Purified recombinant protein of Human high mobility group box 2 (HMGB2), transcript variant 3, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3148
Uniprot URL
https://www.uniprot.org/uniprot/P26583
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001130689
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001124161
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