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BCAT1 (NM_005504) Human Recombinant Protein

Selected Variant

PH31780E1

Size: 50 µg

Product Specifications

Background

This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010]

Overview

Purified recombinant protein of Human branched chain amino-acid transaminase 1, cytosolic (BCAT1), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

BCATC; BCT1; ECA39; MECA39; PNAS121; PP18

Gene ID

586

UniProt

P54687, A0A024RAV0

Accession Number mRNA

NM_005504

Chromosomal Location

12p12.1

Expression System

E. coli

Tag

N-His

Related Pathways

Metabolic pathways, Pantothenate and CoA biosynthesis, Valine, leucine and isoleucine biosynthesis, Valine, leucine and isoleucine degradation

Field of Research

Metabolic pathways, Pantothenate and CoA biosynthesis, Valine, leucine and isoleucine biosynthesis, Valine, leucine and isoleucine degradation

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.

Function

Druggable Genome

Molecular Weight

42.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

BCAT1

Species

Human

Protein ID

NP_005495

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/586

Uniprot URL

https://www.uniprot.org/uniprot/P54687

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_005504

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_005495

Price

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