MRAS (NM_012219) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Overview

Purified recombinant protein of Human muscle RAS oncogene homolog (MRAS), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

M-RAs; NS11; R-RAS3; RRAS3

Gene ID

22808

UniProt

O14807, Q6FGP0, Q8WVM9

Accession Number mRNA

NM_012219

Chromosomal Location

3q22.3

Expression System

E. coli

Tag

N-His

Related Pathways

MAPK signaling pathway, Regulation of actin cytoskeleton, Tight junction

Field of Research

MAPK signaling pathway, Regulation of actin cytoskeleton, Tight junction

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.

Function

Druggable Genome

Molecular Weight

23.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.