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HES1 (NM_005524) Human Recombinant Protein

Product Specifications

Background

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]

Synonyms

BHLHb39; HES-1; HHL; HRY

Gene ID

3280

UniProt

Q14469

Accession Number mRNA

NM_005524

Chromosomal Location

3q29

Expression System

E. coli

Tag

N-His

Related Pathways

Maturity onset diabetes of the young, Notch signaling pathway

Field of Research

Maturity onset diabetes of the young, Notch signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.

Function

Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Transcription Factors

Molecular Weight

29.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

HES1

Species

Human

Protein ID

NP_005515

Overview

Purified recombinant protein of Human hairy and enhancer of split 1, (Drosophila) (HES1), with N-terminal HIS tag, expressed in E.Coli, 50ug

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/3280

Uniprot URL

https://www.uniprot.org/uniprot/Q14469

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_005524

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_005515

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