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PRODH (NM_016335) Human Recombinant Protein

Product Specifications

Background

This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4) . This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

Overview

Purified recombinant protein of Human proline dehydrogenase (oxidase) 1 (PRODH), nuclear gene encoding mitochondrial protein, transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

Synonyms

HSPOX2; PIG6; POX; PRODH1; PRODH2; TP53I6

Gene ID

5625

UniProt

O43272

Accession Number mRNA

NM_016335

Chromosomal Location

22q11.21

Expression System

E. coli

Tag

N-His

Related Pathways

Arginine and proline metabolism, Metabolic pathways

Field of Research

Arginine and proline metabolism, Metabolic pathways

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.

Function

Druggable Genome

Molecular Weight

67.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

PRODH

Species

Human

Protein ID

NP_057419

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/5625

Uniprot URL

https://www.uniprot.org/uniprot/O43272

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_016335

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_057419

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