KIAA1970 (EARS2) (NM_001083614) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12) . Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Synonyms
COXPD12; gluRS; MSE1; mtGlnRS
Gene ID
124454
UniProt
Q5JPH6
Accession Number mRNA
NM_001083614
Chromosomal Location
16p12.2
Expression System
E. coli
Tag
N-His
Related Pathways
Aminoacyl-tRNA biosynthesis, Metabolic pathways, Porphyrin and chlorophyll metabolism
Field of Research
Aminoacyl-tRNA biosynthesis, Metabolic pathways, Porphyrin and chlorophyll metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Function
Druggable Genome
Molecular Weight
58.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
EARS2
Species
Human
Protein ID
NP_001077083
Overview
Purified recombinant protein of Human glutamyl-tRNA synthetase 2, mitochondrial (putative) (EARS2), nuclear gene encoding mitochondrial protein, transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/124454
Uniprot URL
https://www.uniprot.org/uniprot/Q5JPH6
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001083614
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001077083
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