TAT (NM_000353) Human Recombinant Protein
Product Specifications
Background
This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible cognitive disability. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008]
Overview
Purified recombinant protein of Human tyrosine aminotransferase (TAT), nuclear gene encoding mitochondrial protein, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Synonyms
Tyrosine aminotransferase; tyrosine aminotransferase, cytosolic
Gene ID
6898
UniProt
P17735, A0A140VKB7
Accession Number mRNA
NM_000353
Chromosomal Location
16q22.2
Expression System
E. coli
Tag
N-His
Related Pathways
Cysteine and methionine metabolism, Metabolic pathways, Phenylalanine, tyrosine and tryptophan biosynthesis, Phenylalanine metabolism, Tyrosine metabolism, Ubiquinone and other terpenoid-quinone biosynthesis
Field of Research
Cysteine and methionine metabolism, Metabolic pathways, Phenylalanine, tyrosine and tryptophan biosynthesis, Phenylalanine metabolism, Tyrosine metabolism, Ubiquinone and other terpenoid-quinone biosynthesis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Function
Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS
Molecular Weight
50.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TAT
Species
Human
Protein ID
NP_000344
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6898
Uniprot URL
https://www.uniprot.org/uniprot/P17735
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000353
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000344
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