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CABLES1 (NM_138375) Human Recombinant Protein

Product Specifications

Background

This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127) .Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Overview

Purified recombinant protein of Human Cdk5 and Abl enzyme substrate 1 (CABLES1), transcript variant 1, full length, with N-terminal HIS tag, expressed in E. coli, 50ug

Synonyms

CABL1; CABLES; HsT2563; IK3-1

Gene ID

91768

UniProt

Q8TDN4, A0A024RC20

Accession Number mRNA

NM_138375

Chromosomal Location

18q11.2

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1 % Sarkosyl.

Molecular Weight

41.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

CABLES1

Species

Human

Protein ID

NP_612384

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/91768

Uniprot URL

https://www.uniprot.org/uniprot/Q8TDN4

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_138375

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_612384

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