SMAD5 (NM_005903) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Synonyms
DWFC; JV5-1; MADH5
Gene ID
4090
UniProt
Q99717, Q68DB7
Accession Number mRNA
NM_005903
Chromosomal Location
5q31.1
Expression System
E. coli
Tag
N-His
Related Pathways
TGF-beta signaling pathway
Field of Research
TGF-beta signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1 % Sarkosyl.
Function
Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transcription Factors
Molecular Weight
52.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SMAD5
Species
Human
Protein ID
NP_005894
Overview
Purified recombinant protein of Human SMAD family member 5 (SMAD5), transcript variant 1, full length, with N-terminal HIS tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4090
Uniprot URL
https://www.uniprot.org/uniprot/Q99717
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005903
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005894
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