SHB (NM_003028) Human Recombinant Protein

Product Specifications

Background

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Human Src homology 2 domain containing adaptor protein B (SHB), full length, with N-terminal HIS tag, expressed in E. coli, 50ug

Synonyms

BA3J10.2

Gene ID

6461

UniProt

Q15464

Accession Number mRNA

NM_003028

Chromosomal Location

9p13.1

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1 % Sarkosyl.

Function

ES Cell Differentiation/IPS

Molecular Weight

54.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.