C12orf32 (NM_031465) Human Recombinant Protein
Product Specifications
Background
Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation.[UniProtKB/Swiss-Prot Function]
Synonyms
Chromosome 12 open reading frame 32; HKMT1188; HKMT1188, MGC13204; MGC13204
Gene ID
83695
UniProt
Q9BSD3
Accession Number mRNA
NM_031465
Chromosomal Location
12p13.33
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1 % Sarkosyl.
Molecular Weight
26.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
C12orf32
Species
Human
Protein ID
NP_113653
Overview
Purified recombinant protein of Human chromosome 12 open reading frame 32 (C12orf32), full length, with N-terminal HIS tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/83695
Uniprot URL
https://www.uniprot.org/uniprot/Q9BSD3
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_031465
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_113653
Curated Selection
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