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PLAGL1 (NM_001080955) Human Recombinant Protein

Product Specifications

Background

This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM) . Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]

Overview

Purified recombinant protein of Human pleiomorphic adenoma gene-like 1 (PLAGL1), transcript variant 7, full length, with N-terminal HIS tag, expressed in E. coli, 50ug

Synonyms

LOT1; ZAC; ZAC1

Gene ID

5325

UniProt

Q9UM63, A1YLA2, Q9UM63-2

Accession Number mRNA

NM_001080955

Chromosomal Location

6q24.2

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 500mM NaCl, 10% glycerol.

Function

Transcription Factors

Molecular Weight

44.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

PLAGL1

Species

Human

Protein ID

NP_001074424

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/5325

Uniprot URL

https://www.uniprot.org/uniprot/Q9UM63

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001080955

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001074424

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