EMAP II (AIMP1) (NM_004757) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]
Overview
Purified recombinant protein of Human aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1), transcript variant 1, full length, with N-terminal HIS tag, expressed in E. coli, 50ug
Synonyms
EMAP2; EMAPII; HLD3; p43; SCYE1
Gene ID
9255
UniProt
Q12904
Accession Number mRNA
NM_004757
Chromosomal Location
4q24
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1 % Sarkosyl.
Function
Druggable Genome
Molecular Weight
34.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
AIMP1
Species
Human
Protein ID
NP_004748
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9255
Uniprot URL
https://www.uniprot.org/uniprot/Q12904
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004757
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004748
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