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EMAP II (AIMP1) (NM_004757) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]

Overview

Purified recombinant protein of Human aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1), transcript variant 1, full length, with N-terminal HIS tag, expressed in E. coli, 50ug

Synonyms

EMAP2; EMAPII; HLD3; p43; SCYE1

Gene ID

9255

UniProt

Q12904

Accession Number mRNA

NM_004757

Chromosomal Location

4q24

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1 % Sarkosyl.

Function

Druggable Genome

Molecular Weight

34.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

AIMP1

Species

Human

Protein ID

NP_004748

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/9255

Uniprot URL

https://www.uniprot.org/uniprot/Q12904

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_004757

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_004748

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