Slap (SLA) (NM_001045557) Human Recombinant Protein
Product Specifications
Background
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.[UniProtKB/Swiss-Prot Function]
Synonyms
SLA1; SLAP
Gene ID
6503
UniProt
Q13239
Accession Number mRNA
NM_001045557
Chromosomal Location
8q24.22
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1 % Sarkosyl.
Function
Druggable Genome
Molecular Weight
32.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SLA
Species
Human
Protein ID
NP_001039022
Overview
Purified recombinant protein of Human Src-like-adaptor (SLA), transcript variant 2, full length, with N-terminal HIS tag, expressed in E.coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/6503
Uniprot URL
https://www.uniprot.org/uniprot/Q13239
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001045557
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001039022
Curated Selection
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