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Placental lactogen (CSH2) (NM_022644) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human chorionic somatomammotropin hormone 2 (CSH2), transcript variant 2, full length, with N-terminal HIS tag, expressed in E. coli, 50ug

Synonyms

CS-2; CSB; GHB1; hCS-B; PL

Gene ID

1443

UniProt

A6NIT4

Accession Number mRNA

NM_022644

Chromosomal Location

17q23.3

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, 8M Urea, pH8.0.

Function

Secreted Protein

Molecular Weight

18.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

CSH2

Species

Human

Protein ID

NP_072170

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/1443

Uniprot URL

https://www.uniprot.org/uniprot/A6NIT4

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_022644

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_072170

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