BMP4 (NM_001202) Human Recombinant Protein
Product Specifications
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]
Synonyms
BMP2B; BMP2B1; MCOPS6; OFC11; ZYME
Gene ID
652
UniProt
P12644, Q53XC5
Accession Number mRNA
NM_001202
Chromosomal Location
14q22.2
Expression System
E. coli
Tag
N-His
Related Pathways
Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer, TGF-beta signaling pathway
Field of Research
Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer, TGF-beta signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, 8M Urea, pH8.0.
Function
Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway
Molecular Weight
46.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
BMP4
Species
Human
Protein ID
NP_001193
Overview
Purified recombinant protein of Human bone morphogenetic protein 4 (BMP4), transcript variant 11, full length, with N-terminal HIS tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/652
Uniprot URL
https://www.uniprot.org/uniprot/P12644
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001202
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001193
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