Thymidine Kinase 2 (TK2) (NM_004614) Human Recombinant Protein
Product Specifications
Background
This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]
Synonyms
MTDPS2; MTTK; PEOB3; SCA31
Gene ID
7084
UniProt
O00142, Q8IZR3
Accession Number mRNA
NM_004614
Chromosomal Location
16q21
Expression System
E. coli
Tag
N-His
Related Pathways
Drug metabolism - other enzymes, Metabolic pathways, Pyrimidine metabolism
Field of Research
Drug metabolism - other enzymes, Metabolic pathways, Pyrimidine metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, 8M Urea, pH8.0.
Function
Druggable Genome
Molecular Weight
27.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TK2
Species
Human
Protein ID
NP_004605
Overview
Purified recombinant protein of Human thymidine kinase 2, mitochondrial (TK2), nuclear gene encoding mitochondrial protein, transcript variant 1, full length, with N-terminal HIS tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7084
Uniprot URL
https://www.uniprot.org/uniprot/O00142
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004614
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004605
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