Thymidine Kinase 2 (TK2) (NM_004614) Human Recombinant Protein

Product Specifications

Background

This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]

Overview

Purified recombinant protein of Human thymidine kinase 2, mitochondrial (TK2), nuclear gene encoding mitochondrial protein, transcript variant 1, full length, with N-terminal HIS tag, expressed in E. coli, 50ug

Synonyms

MTDPS2; MTTK; PEOB3; SCA31

Gene ID

7084

UniProt

O00142, Q8IZR3

Accession Number mRNA

NM_004614

Chromosomal Location

16q21

Expression System

E. coli

Tag

N-His

Related Pathways

Drug metabolism - other enzymes, Metabolic pathways, Pyrimidine metabolism

Field of Research

Drug metabolism - other enzymes, Metabolic pathways, Pyrimidine metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, 8M Urea, pH8.0.

Function

Druggable Genome

Molecular Weight

27.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.