SPDYA (NM_001142634) Human Recombinant Protein
Product Specifications
Background
Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:12972555) . Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation (PubMed:28666995) . Mediates cell survival during the DNA damage process through activation of CDK2 (PubMed:12839962) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Human speedy homolog A (Xenopus laevis) (SPDYA), transcript variant 3, full length, with N-terminal HIS tag, expressed in E. coli, 50ug
Synonyms
RINGO3; RINGOA; SPDY1; SPY1
Gene ID
245711
UniProt
Q5MJ70, A0A384MTT5
Accession Number mRNA
NM_001142634
Chromosomal Location
2p23.2
Expression System
E. coli
Tag
N-His
Related Pathways
Oocyte meiosis, Progesterone-mediated oocyte maturation
Field of Research
Oocyte meiosis, Progesterone-mediated oocyte maturation
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, 8M Urea, pH8.0.
Molecular Weight
36.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SPDYA
Species
Human
Protein ID
NP_001136106
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/245711
Uniprot URL
https://www.uniprot.org/uniprot/Q5MJ70
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001142634
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001136106
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