LKB1 (STK11) (NM_000455) Human Recombinant Protein

Product Specifications

Background

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human serine/threonine kinase 11 (STK11), full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

Synonyms

HLKB1; LKB1; PJS

Gene ID

6794

UniProt

Q15831, A0A0S2Z4D1

Accession Number mRNA

NM_000455

Chromosomal Location

19p13.3

Expression System

E. coli

Tag

N-GST and C-His

Related Pathways

Adipocytokine signaling pathway, mTOR signaling pathway

Field of Research

Adipocytokine signaling pathway, mTOR signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.

Function

Druggable Genome, Protein Kinase

Molecular Weight

74.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.